Gene expression following HIV-1 infection

Gene therapy for HIV-1 infection.

Gene Therapy for HIV-1 Infection

Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients

Background and Aims: Human T-lymphotropic virus type 1 (HTLV-1) is a member of retroviridae family that causes ATL and HAM/TSP. Many inflammatory diseases are associated with this virus, such as Sjögren's syndrome, Hashimoto's thyroiditis, Uveitis and also Atherosclerosis. HTLV-1 performs in long latency period and can activate the immune responses in coronary vessels. Activated immune sys...

SRSF1 inhibition of HIV-1 gene expression

The treatment of HIV-1 infected patients is mostly based on compounds that directly target the activity of proteins coded by the virus. However, the viral genome mutates at a rapid rate, generating drug resistant strains, hence the need for novel drugs to outpace the adaptive mechanisms of the virus. Since cellular factors, which are required for the efficient expression of the HIV-1 genome, do...

HIV-1 Clade B pol Evolution following Primary Infection

OBJECTIVE Characterize intra-individual HIV-1 subtype B pol evolution in antiretroviral naive individuals. DESIGN Longitudinal cohort study of individuals enrolled during primary infection. METHODS Eligible individuals were antiretroviral naïve participants enrolled in the cohort from December 1997-December 2005 and having at least two blood samples available with the first one collected wi...